Stammdaten

Titel: Lack of adverse effects in subchronic and chronic toxicity/carcinogenicity studies on the glyphosate-resistant genetically modified maize NK603 in Wistar Han RCC rats
Untertitel:
Kurzfassung:

In 2012, a controversial study on the long-term toxicity of a Roundup herbicide and the glyphosate-tolerant genetically modified (GM) maize NK603 was published. The EC-funded G-TwYST research consortium tested the potential subchronic and chronic toxicity as well as the carcinogenicity of the glyphosate-resistant genetically modified maize NK603 by performing two 90-day feeding trials, one with GM maize inclusion rates of 11 and 33% and one with inclusion rates of up to 50%, as well as a 2-year feeding trial with inclusion rates of 11 and 33% in male and female Wistar Han RCC rats by taking into account OECD Guidelines for the testing of chemicals and EFSA recommendations on the safety testing of whole-food/feed in laboratory animals. In all three trials, the NK603 maize, untreated and treated once with Roundup during its cultivation, and the conventional counterpart were tested. Differences between each test group and the control group were evaluated. Equivalence was assessed by comparing the observed difference to differences between non-GM reference groups in previous studies. In case of significant differences, whether the effects were dose-related and/or accompanied by changes in related parameters including histopathological findings was evaluated. It is concluded that no adverse effects related to the feeding of the NK603 maize cultivated with or without Roundup for up to 2 years were observed. Based on the outcome of the subchronic and combined chronic toxicity/carcinogenicity studies, recommendations on the scientific justification and added value of long-term feeding trials in the GM plant risk assessment process are presented.

Schlagworte: Genetically modified maize NK603; GMO risk assessment; Biosafety; G-TwYST; OECD Test Guideline No. 408; OECD Test Guideline No. 453; Rat feeding trial; Subchronic oral toxicity study; Combined chronic toxicity; carcinogenicity study
Publikationstyp: Beitrag in Zeitschrift (Autorenschaft)
Art der Veröffentlichung Online Publikation
Erschienen in: Archives in Toxicology
Archives in Toxicology
zur Publikation
 ( Springer International Publishing AG; A. Spök )
Erscheinungsdatum: 12.02.2019
Titel der Serie: -
Bandnummer: 93
Heftnummer: 4
Erstveröffentlichung: Ja
Version: -
Seite: S. 1095 - 1139

Identifikatoren

ISBN: -
ISSN: 1432-0738
DOI: http://dx.doi.org/10.1007/s00204-019-02400-1
AC-Nummer: -
Homepage: https://link.springer.com/article/10.1007/s00204-019-02400-1
Open Access
  • Online verfügbar (Open Access)

AutorInnen

Pablo Steinberg (extern)
Hilko van der Voet (extern)
Paul W. Goedhart (extern)
Gijs Kleter (extern)
Esther J. Kok (extern)
Maria Pla (extern)
Anna Nadal (extern)
Dagmar Zeljenková (extern)
Radka Aláčová (extern)
Júlia Babincová (extern)
Eva Rollerová (extern)
Soňa Jaďuďová (extern)
Anton Kebis (extern)
Elena Szabova (extern)
Jana Tulinská (extern)
Aurélia Líšková (extern)
Melinda Takácsová (extern)
Miroslava Lehotská Mikušová (extern)
Zora Krivošíková (extern)
Armin Spök (intern)
Monica Racovita (intern)
Huib de Vriend (extern)
Roger Alison (extern)
Clare Alison (extern)
Wolfgang Baumgärtner (extern)
Kathrin Becker (extern)
Charlotte Lempp (extern)
Marion Schmicke (extern)
Dieter Schrenk (extern)
Annette Poeting (extern)
Joachim Schiemann (extern)
Ralf Wilhelm (extern)

Zuordnung

Organisation Adresse
Fakultät für Interdisziplinäre Forschung und Fortbildung
 
Institut für Technik- und Wissenschaftsforschung
B07b (LS) / Universitätsstraße 65-67
9020 Klagenfurt am Wörthersee
Österreich
   andrea.lassnig@aau.at
https://www.aau.at/technik-und-wissenschaftsforschung
zur Organisation
B07b (LS) / Universitätsstraße 65-67
AT - 9020  Klagenfurt am Wörthersee

Kategorisierung

Sachgebiete
  • 107007 - Risikoforschung (211914)
  • 301211 - Toxikologie
  • 509017 - Wissenschaftsforschung
Forschungscluster Kein Forschungscluster ausgewählt
Zitationsindex
  • Science Citation Index Expanded (SCI Expanded)
Informationen zum Zitationsindex: Master Journal List
Peer Reviewed
  • Ja
Publikationsfokus
  • Science to Science (Qualitätsindikator: n.a.)
Klassifikationsraster der zugeordneten Organisationseinheiten:
Arbeitsgruppen Keine Arbeitsgruppe ausgewählt

Kooperationen

Organisation Adresse
University of Veterinary Medicine Hannover, Institute for Food Toxicology
Hannover
Deutschland
DE  Hannover
Wageningen University and Research, Biometris
Wageningen
Niederlande
NL  Wageningen
RIKILT Wageningen University & Research
Wageningen
Niederlande
NL  Wageningen
University of Girona, Institute of Food and Agricultural Technology
Girona
Spanien
ES  Girona
CRAG-CSIC-IRTA-UAB-UB, Edifici CRAG
Cerdanyola
Spanien
ES  Cerdanyola
Slovak Medical University, Faculty of Public Health
Bratislava
Slowakei
SK  Bratislava
Slovak Medical University, Faculty of Medicine
Bratislava
Slowakei
SK  Bratislava
Technische Universität Graz
Rechbauerstraße 12
8010 Graz
Österreich - Steiermark
Rechbauerstraße 12
AT - 8010  Graz
LIS Consult (LIS)
Niederlande
NL  
Roger Alison Ltd.
Lampeter
Großbrit. u. Nordirland
GB  Lampeter
University of Veterinary Medicine Hannover, Department of Pathology
Hannover
Deutschland
DE  Hannover
University of Veterinary Medicine Hannover, Clinic for Cattle
Hannover
Deutschland
DE  Hannover
University of Kaiserslautern, Food Chemistry and Toxicology
Kaiserslautern
Deutschland
DE  Kaiserslautern
Federal Institute for Risk Assessment
Berlin
Deutschland
DE  Berlin
Institute for Biosafety in Plant Biotechnology, Julius Kühn-Institut (JKI), Federal Research Centre for Cultivated Plants
Quedlinburg
Deutschland
DE  Quedlinburg
Max Rubner-Institut, Federal Research Institute of Nutrition and Food
Karlsruhe
Deutschland
DE  Karlsruhe
Global Sustainability Institute, Anglia Ruskin University
Cambridge
Großbrit. u. Nordirland
GB  Cambridge

Beiträge der Publikation

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